Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.81% | 987.96 | 25 MG
SJ1008030 TFA is a JAK2 PROTAC designed to selectively degrade JAK2. This compound has demonstrated potent inhibitory effects on MHH-CALL-4 cell growth with an IC50 of 5.4 nM, making it a valuable tool for leukemia research.
- Selectively degrades JAK2.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Useful for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC Claramine TFA | 3030428-57-7 | 95.0% | 703.02 | 5 MG
Claramine TFA is a steroidal polyamine that regulates the properties of lipid membranes and offers protection to cells against various biological toxins. These toxins include misfolded protein oligomers and those derived from biological proteins.
- Does not affect cell viability in human neuroblastoma cells (sh-sy5y) at concentrations below 10 μM.
- Does not impact cell activity in hek293 cells.
- Protects human neuroblastoma (sh-sy5y) cells from the harmful effects of pore-forming agents, melittin and α-hemolysin, by inhibiting their binding to cell membranes.
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438811-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG
PSEM 89S TFA is a selective and brain penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance.
- Reversibly silences transfected neurons by reducing cellular input resistance.
- Reduces photostimulation-evoked feeding in mice with PSAML141F,Y115F-glycine receptor.
- Demonstrates good brain penetrance in mice after intraperitoneal administration.
- Suppresses fos in ChR2-expressing neurons in Agrp-cre mice.
- Shows rapid rise in serum and brain, cleared within 1 hour in C57BL/6 mice.
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 1 MG
PBX-7011 TFA is a derivative of camptothecin, which inhibits the expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells. It degrades DDX5 proteins and exhibits anticancer activity. This product is for research use only and not sold to patients.
- Inhibits expression of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
- Targets Bcl-2 family and Survivin.
- Involves the apoptosis pathway.
- Is a derivative of camptothecin.
Medchemexpress LLC PBX-7011 TFA | 3003834-30-5 | 98.6% | 561.46 | 1 ML
PBX-7011 TFA is a derivative of camptothecin that inhibits the expression of cancer-related survival genes and degrades DDX5 proteins.
- Inhibits expression of cancer-related survival genes (DDX5, Survivin, Mcl-1, and XIAP in FaDu cells).
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC Gln-AMS TFA | 209543-57-7 | >99.85% | 588.47 | 1 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is for research use only.
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM
Medchemexpress LLC Tam557 Tfa | 98.5% | 1119.34 | 5 MG
TAM557 TFA is a cytotoxic tubulysin compound modified for conjugation to transport vehicles such as proteins, peptides, small molecules, or polymeric carriers that can carry a targeting principle. It is for research use only and not sold to patients.
- Cytotoxic tubulysin compound
- Modified for conjugation to transport vehicles
- Available in 1 mg, 5 mg, 10 mg, and 50 mg sizes
Medchemexpress LLC Ms15 TFA | C66H80F3N11O7S | 5 MG
MS15 TFA is a potent and selective AKT PROTAC degrader for research use only. It effectively inhibits AKT1, AKT2, and AKT3 activities, demonstrating bioavailability in mice through intraperitoneal administration.
- Potent and selective AKT PROTAC degrader
- Inhibits AKT1, -2, and -3 activities
- IC50 values: 798 nM (AKT-1), 90 nM (AKT-2), 544 nM (AKT-3)
- Bioavailable in mice via intraperitoneal administration
- Purity of 99.82%
Medchemexpress LLC Gln-AMS (TFA) | 99.9% | 588.47 | 25 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor that inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is provided as a solid, white to off-white in appearance, and is stable under recommended storage conditions, making it suitable for laboratory research in metabolic enzyme, protease, anti-infection, and bacterial studies.
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
- Available in various quantities for research needs.
- Stable under recommended storage conditions.
- Suitable for in vitro and in vivo dissolution protocols.
Medchemexpress LLC Cl2e-SN-38 TFA | 99.5% | 1855.95 | C89H117F3N14O26 | 1 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) linker-payload provided as the trifluoroacetate (TFA) salt. It incorporates SN-38, the active metabolite of irinotecan, and is intended for research use in ADC development and preclinical studies.
- Highly releasable linker-SN-38 conjugate suitable for ADC research.
- Provided as the trifluoroacetate salt to aid handling and formulation.
- Molecular weight 1855.95 and formula C89H117F3N14O26.
- High purity (reported ~99.5%).
- Available in milligram-scale quantities for assay development and conjugation experiments.