Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Pep42 TFA | 99.6% | 1335.59 | 1 MG
Pep42 TFA is a cyclic peptide ligand of GPR78. It internalizes selectively into highly metastatic human melanoma cells through a receptor-mediated process. This product is for research use only and not sold to patients.
- Cyclic peptide ligand of GPR78
- Selectively internalizes into highly metastatic human melanoma cells
Medchemexpress LLC Stressin I TFA | 98.6% | 4472.20 | 5 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist with a Ki of 1.7 nM. It induces an increase in adrenocorticotropic hormone (ACTH) levels in rats. This product is for research use only and not sold to patients.
- Potent CRF1 receptor selective agonist
- Induces increase in adrenocorticotropic hormone (ACTH) levels
- White to off-white solid appearance
- For research use only
Medchemexpress LLC NTPA TFA | 99.8% | 1773.36 (free base) | 500 UG
NTPA TFA is a polycarboxylic acid ligand that participates in the coordination reaction with metal ions to form complexes.
- Appearance: Solid
- Color: White to off-white
- Molecular formula: C82H161N31O12.xC2HF3O2
- Sequence: C17H35CONH-Pro-Lys-Lys-Lys-Arg-Lys-Val-Arg-Arg-Arg-Arg-NH2
- Storage: Sealed storage away from moisture; Powder: -80°C for 2 years, -20°C for 1 year; In solvent: -80°C for 6 months, -20°C for 1 month.
- Solubility: 50 mg/mL in DMSO (ultrasonic may be needed).
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.1% | 2675.03 | 2 MG
KRpep-2d is a potent inhibitor of K-Ras, designed to impede the proliferation of K-Ras-driven cancer cells. It is suitable for use in cancer research. The product possesses a cyclic structure, which is crucial for its K-Ras inhibitory activity, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for this function.
- Potently inhibits K-Ras activity.
- Reduces the proliferation of cancer cells driven by K-Ras.
- Features a cyclic structure important for its inhibitory action.
- Critical amino acid residues contribute to its effectiveness.
- Can be used for cancer research applications.
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 100 UG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for ADAMTS13 assay, with excitation at 340 nm and emission at 450 nm. It is utilized as a predictive tool for thrombotic thrombocytopenic purpura. This product is a light yellow to yellow solid with a molecular weight of 8314.28 and a purity of 97.3%.
- Serves as a fluorogenic substrate for ADAMTS13 assay
- Utilized as a predictive tool for thrombotic thrombocytopenic purpura
- Purity confirmed by HPLC
- Light yellow to yellow solid appearance
Medchemexpress LLC Stressin I TFA | 98.63% | 4472.20 (free base) | 1 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent and selective agonist for the CRF1 receptor, intended for research use only. It has been shown to increase adrenocorticotropic hormone (ACTH) levels in rats.
- Potent CRF1 receptor selective agonist
- Ki of 1.7 nM
- Increases adrenocorticotropic hormone (ACTH) levels in rats
Medchemexpress LLC Angiopeptin TFA | 2478421-60-0 | 99.01% | 1326.39 | 25 MG
Angiopeptin TFA is a cyclic octapeptide analogue of somatostatin. It acts as a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. It is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA also inhibits adenylate cyclase or stimulates extracellular acidification, making it valuable for research in coronary atherosclerosis.
- Acts as a partial agonist on the release of tritium on CHO hsst2 cells (in vitro).
- Significantly inhibits neointimal formation (in vivo).
- Significantly inhibits coronary artery myointimal proliferation in cardiac allografts (in vivo).
Medchemexpress LLC Fsllry-nh2 tfa | 245329-02-6 | 99.7% | 910.98 | 10 MG
FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor used for research purposes. Treatment with FSLLRY-NH2 has been shown to significantly improve neurological outcome and reduce the number of degenerating hippocampal neurons after ACA (asphyxial CA).
- Protease-activated receptor 2 (PAR2) inhibitor
- Significantly improves neurological outcome after cardiac arrest in rats
- Reduces degenerating hippocampal neurons after asphyxial CA
- For research use only
Medchemexpress LLC Egfr-in-1 Tfa | 2753348-63-7 | 99.4% | 628.60 | 1 ML
Egfr-in-1 Tfa | 2753348-63-7 | 99.4% | 628.60 | 1 ML
Medchemexpress LLC Cppi9 Tfa | 99.9% | 1553.37 | 5 MG
CPP9 TFA is a small, amphipathic, cyclic cell-penetrating peptide (CPP) that binds directly to plasma membrane phospholipids and enters mammalian cells via endocytosis. Its efficient release from the endosome after cellular entry makes it suitable for intracellular delivery of therapeutic agents and chemical probes.
- Efficient release from endosome after cellular entry
- Suitable for intracellular delivery of therapeutic agents
- Suitable for intracellular delivery of chemical probes
- For research use only
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 (free acid) | 500 UG
Charybdotoxin (TFA) is a research-grade peptide supplied as a white to off-white solid. It has a molecular weight of 4295.89 (free acid) and a purity of 96.8% as determined by LCMS. This substance is intended for laboratory use and substance manufacturing, offering stability under recommended storage conditions.
- Supplied as a white to off-white solid
- Purity of 96.8% (LCMS)
- Molecular weight of 4295.89 (free acid)
- Suitable for use as laboratory chemical and for substance manufacturing
- Stable under recommended storage conditions
- Store powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Ghrf, mouse (TFA) | 125199-49-7 | 98.9% | 5032.74 | 5 MG
GHRF, mouse (TFA) is a 44-amino acid peptide that stimulates the release and synthesis of growth hormone. This product is for research use only and not intended for patient use.
- 44-amino acid peptide
- Stimulates growth hormone release and synthesis
- High purity of 98.9%
- Molecular weight of 5032.74
- Increases growth hormone levels in LI-IGF-I-/- mice
eMolecules 407-22-7 | 2-Fluoro-6-methylpyridine | Ambeed | MFCD00041226 | 111.119 | C6H6FN | 97.000 | Cc1cccc(F)n1 | 5g | 552650211
2-Fluoro-6-methylpyridine | Ambeed | 407-22-7 | MFCD00041226 | 111.119 | C6H6FN | 97.000 | Cc1cccc(F)n1 | 5g | 552650211
Medchemexpress LLC Pemvidutide (TFA) | C182H275N39O54.xC2HF3O2 | 1 MG
Pemvidutide (ALT-801) TFA is a GLP-1R/GCGR dual agonist that demonstrates significant reductions in body weight, liver fat, and serum lipids. It is utilized in research for non-alcoholic steatohepatitis (NASH) and obesity.
- GLP-1R/GCGR dual agonist
- Causes significant reductions in body weight
- Reduces liver fat
- Reduces serum lipids
- Used in research for non-alcoholic steatohepatitis (NASH)
- Used in obesity research
Medchemexpress LLC Pep42 TFA | 99.6% | 1335.59 | 25 MG
Pep42 TFA is a cyclic peptide ligand of GPR78. It internalizes selectively into highly metastatic human melanoma cells through a receptor-mediated process. This product is for research use only.
- Cyclic peptide ligand of GPR78
- Internalizes selectively into highly metastatic human melanoma cells
- Receptor-mediated process
- Sequence: Cys-Thr-Val-Ala-Leu-Pro-Gly-Gly-Tyr-Val-Arg-Val-Cys (disulfide:Cys1-Cys13)
- Target: Others
- Pathway: Others
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
- Appearance: Solid
- Stable under recommended storage conditions
- Identified uses: Laboratory chemicals, manufacture of substances