Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Medchemexpress LLC Nls-Stax-h (Tfa) | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
Nls-Stax-h is a selective, cell-permeable, stapled peptide that acts as a Wnt signaling inhibitor. It has an Ic50 of 1.4 μM and effectively inhibits β-catenin-transcription factor interactions. This compound demonstrates anti-proliferative effects on cancer cells.
- Selective Wnt signaling inhibitor.
- Cell-permeable.
- Stapled peptide.
- Inhibits β-catenin-transcription factor interactions.
- Shows anti-proliferation of cancer cells.
- Inhibits proliferation of colorectal cancer cells at 10 μM over 72 h, reducing viability by more than 80% in SW-480 and DLD-1 cells.
- Inhibits migration of colorectal cancer cells at 5 and 10 μM over 24 h, resulting in dose-dependent inhibition of wound closure (52% at 5 μM, and 24% at 10 μM in DLD-1 cells).
Medchemexpress LLC JBJ-09-063 (TFA) | 99.6% | 670.67 | 25 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor that effectively reduces EGFR, Akt, and ERK1/2 phosphorylation. It is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models and can be used for researching EGFR-mutant lung cancer. This inhibitor is remarkably effective at inhibiting cell growth, leading to a significant increase in apoptosis, and exhibits favorable pharmacokinetics properties for good efficacy upon oral dosing.
- Mutant-selective allosteric EGFR inhibitor
- Reduces EGFR, Akt, and ERK1/2 phosphorylation
- Effective against EGFR TKI-sensitive and resistant models
- Suitable for EGFR-mutant lung cancer research
- Inhibits cell growth and increases apoptosis
- Favorable pharmacokinetics properties
- Stable for good efficacy upon oral dosing
Medchemexpress LLC Mal-PEG2-NH2 TFA | 660843-23-2 | 99.4% | 342.27 | 50 MG
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein via a linker. The product appears as an oil, light yellow to yellow in color. This product is for research use only and not intended for patient use.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the ubiquitin-proteasome system for selective protein degradation.
- Appears as an oil, light yellow to yellow in color.
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 99.9% | 1188.4 g/mol | C56H85N17O12 · x C2HF3O2 | 5 MG
Lys-bradykinin trifluoroacetate is the trifluoroacetic acid (TFA) salt form of the peptide Lys-Bradykinin (kallidin 380-389). It is supplied as a purified powder for research applications where it serves as a ligand for kallidin and bradykinin receptors. Reported purity is 99.85% and the free-base molecular weight is 1188.38 g/mol.
- TFA salt of Lys-Bradykinin peptide.
- High purity (99.85%).
- Provided as a solid powder suitable for dissolution in common solvents.
- Recommended storage: sealed, protected from moisture and light; powder stable at -80°C for up to 2 years.
- Intended for research use as a ligand in receptor binding or signaling studies.
Medchemexpress LLC HR97 TFA | 1518.84 | 5 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Molecular weight of 1518.84 (free acid)
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Solubility in DMSO: 50 mg/mL (requires ultrasonic)
- Can be used to prepare HR97-SunitiGel eye drops
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC Mm-102 trifluoroacetate | 1883545-52-5 | 99.7% | 1 ML
MM-102 TFA is the trifluoroacetate salt of MM-102, a potent inhibitor of the WDR5/MLL protein-protein interaction, supplied as a ready-to-use 10 mM solution in DMSO for research applications.
- Potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).
- Supplied as a 10 mM solution in DMSO, 1 mL volume.
- High purity listed at 99.68% (reported as 99.7%).
- Molecular weight 783.83 g·mol⁻1; formula C37H50F5N7O6.
- For research use only; not for human or clinical use.
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Charybdotoxin (TFA) | 96.8% | 4295.89 | 1 MG
Medchemexpress LLC Wl47 (TFA) | 99.7% | 1942.32 | 5 MG
WL47 TFA is a high-affinity cavolin-1 (CAV1) ligand that potently disrupts CAV1 oligomers. It shows selectivity for CAV1 over BSA, casein, and HEWL, and is used for studying caveolin-1 function. It is also 80% smaller in length than the original T20 parent sequence.
- High-affinity cavolin-1 (CAV1) ligand (Kd=23 nM)
- Potently disrupts CAV1 oligomers
- Exhibits selectivity for CAV1 over BSA, casein, and HEWL
- Used for studying caveolin-1 function
- 80% smaller in length than original T20 parent sequence